![]() Interstitial fluid provides the immediate microenvironment that allows for movement of ions, proteins and nutrients across the cell barrier. When excessive fluid accumulates in the interstitial space, edema develops. Together with the vascular space, the interstitial space comprises the extracellular space. ![]() Interstitial refers to a "small opening or space between objects". The interstitial compartment (also called extravascular compartment or tissue space) is the space that surrounds the cells of a given tissue. In humans, the intracellular compartment contains on average about 28 litres of fluid, and under ordinary circumstances remains in osmotic equilibrium with the ECF.Įxtracellular Fluid Interstitial Compartment Intracellular fluid is found inside the two-layered plasma membrane of the body's cells, and is the matrix in which cellular organelles are suspended, and chemical reactions take place. Intracellular fluid (ICF), which makes up approximately 60-65% of body water, andĮxtracellular fluid (ECF), which makes up the other 35-40% of body water (for all practical purposes, the only solvent in the body is water). Overviewįluid compartments in the mammalian body broadly comprise two compartments, each with several subdivisions: List of terms related to Fluid compartmentsĮditor-In-Chief: C. Risk calculators and risk factors for Fluid compartmentsĬauses & Risk Factors for Fluid compartmentsĭiagnostic studies for Fluid compartments US National Guidelines Clearinghouse on Fluid compartmentsĭirections to Hospitals Treating Fluid compartments Ongoing Trials on Fluid compartments at Clinical Ĭlinical Trials on Fluid compartments at Google Most cited articles on Fluid compartmentsĪrticles on Fluid compartments in N Eng J Med, Lancet, BMJĬochrane Collaboration on Fluid compartments Fluid movement out of the ICF space attenuated the decrease in the ECF space.Most recent articles on Fluid compartments Free water loss, which is analogous to "free water clearance" in renal function, showed a strongly inverse correlation with in sweat (r = -0.97, P less than 0.001). The increase in plasma osmolality was a function of the loss of free water (delta FW), estimated from the equation delta FW = delta TW - (loss of osmotically active substance in sweat and urine)/(control plasma osmolality) (r = -0.79, P less than 0.01). ![]() The decrease in the ICF space was correlated with the increase in plasma osmolality (r = -0.74, P less than 0.02). The change in the extracellular fluid space (delta ECF) was estimated from chloride distribution and the change in the intracellular fluid space (delta ICF) was calculated by subtracting delta ECF from delta TW. We measured plasma volume, plasma osmolality, and, , and in plasma, together with sweat and urine volumes and their ionic concentrations before and after dehydration. After dehydration, the subjects rested for 1 h in a thermoneutral environment (28 degrees C, less than 30% rh), after which time the changes in the body fluid compartments were assessed. To investigate the influence of in sweat on the distribution of body water during dehydration, we studied 10 volunteer subjects who exercised (40% of maximal aerobic power) in the heat for 90-110 min to produce a dehydration of 2.3% body wt (delta TW).
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